Science  /  Antecedent

America's Devastating First Plague and the Birth of Epidemiology

In the 1790s a plague struck the new American nation and killed thousands. Noah Webster told the story of pandemics and invented a field.

The terror that is gripping Americans due to the coronavirus would be familiar to America’s founding generation. As Noah Webster, then the editor of New York City’s first daily newspaper, wrote to a friend in the fall of 1793, “The melancholy accounts received from you and others of the progress of a fatal disease…excite commiseration in every breast. An alarm is spread over the country.”

The disease was the yellow fever, a virus that attacked the liver and kidneys. This American plague, which got its name because its victims became jaundiced, swept through the nation’s biggest cities a few times between 1793 to 1798. The first outbreak occurred in August of 1793 in Philadelphia, which served as the nation’s capitol from 1790 to 1800. By the middle of that November, the yellow fever would decimate the city, wiping out 5,000 of its 50,000 residents and forcing President Washington and his cabinet to flee to neighboring Germantown. Cool fall temperatures then suddenly stopped this wave of the disease, which, as scientists would determine a century later, was transmitted by mosquitos.

About two years later, New York City was hit particularly hard. Its first recorded patient was Thomas Foster, who sought medical attention from Dr. Malachi Treat, the health officer at the city’s port, on July 6, 1795. As a colleague of Dr. Treat later wrote, Foster’s yellow skin was “covered with purple spots, his mind deranged, his tongue covered with a dry back sordes.” Foster died three days later, and Treat himself was soon gone. By mid-August, two New Yorkers a day were dying, and all afflicted patients were quarantined at Bellevue Hospital. As Webster’s New York neighbor, Dr. Elihu Smith, noted in his diary in September, “The whole city, is in a violent state of alarm on account of the fever. It is the subject of every conversation, at every hour, and in every company.” By late November when this outbreak petered out, 730 New Yorkers had died—the equivalent of about 200,000 today, as the city then had a population of about 40,000

That fall, Webster, who is best known to us today for his monumental dictionary of American English published in 1828, sprang into action. In late October, he published a circular in his paper, The American Minerva, addressed to the physicians in the cities most affected by the fever over the past three years—Philadelphia, New York, Baltimore, Norfolk and New Haven—which asked them to pass on whatever information that they had gathered from their own practices.